Sponsored by China Association of Chinese Medicine
ISSN 1673-7717 CN 21-1546/R
12 issues per year
Discipline(s): Medical Science
Current Issue: Issue 10, 2018
Chinese Archives of Traditional Chinese Medicine is supervised by State Administration of Traditional Chinese Medicine of the People's Republic of China and sponsored by China Association of Chinese Medicine. The journal publishes the latest research achievements of specialists, scholars，and the phased development of scientific research projects on different grades, and keeps synchronized development with academic research of TCM. Meanwhile, it prepares a green channel for thesis of national scientific research projects to be published in priority. The journal is included in CA.
Wang Yongyan;Shi Xuemin;
Zhang Boli;Kang Tingguo;
Infrared Spectra Analysis of Orostachys cartilaginea, Orostachys malacophyllus and Rhodiola sachalinensis Extracts
Vol 36,No. 10
Objective: Identification method for infrared spectra of Orostachys cartilaginea, Orostachys malacophyllus, and Rhodiola sachalinensis was investigated. Methods: Petroleum ether, methanol, and ethyl acetate were used to extract O. cartilaginea, O. malacophyllus, and R. sachalinensis from Changbai Mountain, respectively. The FT-IR (Fourier transform infrared spectroscopy) spectra of these extracts was determined. In the end, the pattern of FT-IR spectra was compared with SPSS (Statistical Product and Service Solutions. Results: FT-IR spectra of O. cartilaginea and O. malacophyllus had common and different peaks. Furthermore, FT-IR spectra of methanol extracts of O. cartilaginea and O. malacophyllus ccould be used to distinguish them. Conclusion: This method is rapid, simple, and characteristic, providing the reference for the identification and selection of Crassulaceae species.
Effect of Jiangtang Shuxin Recipe on Endoplasmic Reticulum Stress c-JNK Apoptosis Pathway in Diabetic Myocardium
Vol 36,No. 10
Objective: To investigate the molecular mechanism of Jiangtang Shuxin (JTSX) Recipe in inhibiting endoplasmic reticulum stress c-JNK apoptotic pathway and reducing myocardial remodeling in SD diabetic rats. Methods: Type 2 diabetes model was established in male SD rats by injecting streptozotocin and feeding high lipid diet. After T2DM models were established successfully, the rats were divided into model group, western medicine group (gliquidone + benazepril), low-dose JTSX (JTSX 1) group and high-dose JTSX (JTSX 2) group. Another normal group was set up. After eight weeks of corresponding drug intervention, the levels of fasting blood glucose (FBG), serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) were measured. The ultrastructure of myocardial tissue was observed under transmission electron microscope. TUNEL was used to detect cardiomyocyte apoptosis. The mRNA and their functional protein levels of c-Jun N-terminal kinases (c-JNK) and glucose-regulated protein78 (GRP78) were determined by the method of RT-PCR and immunohistochemistry respectively. Results: Compared with model group, after drugs intervention, all administered groups could significantly decrease FPG ( P < 0.05), elevate SOD and GSH-Px activity ( P < 0.05), depress the levels of TG and LDL-C ( P < 0.05), raise HDL-C ( P < 0.05), decline the mRNA transcription and their functional protein expression of the c-JNK and GRP78 ( P < 0.05), reduce cardiomyocyte apoptosis index (AI) ( P < 0.05) and improve the ultrastructure of myocardial tissue. Compared with Western medicine group, the JTSX 2 effect was more significant ( P < 0.05). Conclusion: JTSX can improve metabolic disorders in diabetes mellitus, ameliorate the ability of antioxidant stress, suppress endoplasmic reticulum stress apoptosis c-JNK pathway, and therefore improve myocardial remodeling, and the therapeutic effect was dose-dependent.