Sponsored by Liaoning university of Chinese medicine
ISSN 1000-1719 CN 21-1128/R
12 issues per year
Discipline(s): Medical Science
Current Issue: Issue 07, 2018
Liaoning Journal of Traditional Chinese Medicine is supervised by Health and Family Planning Committee of Liaoning Province and sponsored by Liaoning University of Chinese Medicine. Launched in 1958, the journal is a comprehensive traditional Chinese medicine journal. Research articles published in this journal is to serve researchers for studying traditional Chinese medicine, physician of integrated traditional Chinese and Western Medicine, and TCM students and amateurs interested in traditional Chinese medicine. The journal is included in CA.
Executive Vice Editor-in-Chief
Effects of PKA-CREB Pathway Participating in Expressions of AQP1 and AQP3 Genes in Degenerative Intervertebral Disc by Electroacupuncture
Vol 45,No. 07
Objective: To study the effect of electroacupuncture (EA) at Jiaji (EX-B 2) on the expression of phosphorylated camp response element binding protein ( p CREB) in degenerated intervertebral discs of rabbits and investigate the possible mechanism of PKA-CREB pathway involved in the regulation of Aquaporin s 1 and 3 ( AQPs 1 and 3) gene expressions in endplate chondrocytes by EA. Methods: Fifty healthy male mature New Zealand rabbits were randomly divided into normal group, sham model group, model group, model + EA group, and model + EA + H89 group, with 10 rats in each group. The intervertebral disc degeneration model was replicated by the compression of Kirschner wire across the vertebral body. EA group was treated with acupuncture at L4 and L5 Jiaji (EX-B 2) points for 28 days. When the normal group and the sham model group finished the modeling course, five rabbits were taken from the remaining three groups respectively for L4–5 disc MRI examination after the success of the modeling on the first day and twenty-eighth day and then we took out the disc tissue for enzyme linked immunosorbent assay ( ELISA), Western Blot and Real-time PCR detection. Results: The MRI (T2 weighted) scan showed that the degenerative intervertebral disc signal after EA treatment was stronger than that in the model group. After the success of modeling, the expressions of c AMP dependent protein kinase A (PKA), p CREB and AQPs 1 and 3 mRNA were decreased ( P < 0.05). The expressions of PKA, p CREB and AQPs 1 and 3 mRNA after the intervention of EA treatment were increased ( P < 0.05). H89 could inhibit the expression of PKA ( P < 0.05), reverse the effect of EA on up regulation of p CREB expression ( P < 0.05) and decrease the expressions of AQPs 1 and 3 mRNA ( P < 0.05). Conclusion: EA at Jiaji (EX-B 2) points can improve the expression of PKA-CREB pathway, increase the transcription of AQPs 1 and 3 mRNA, promote the expression of AQPs 1 and 3 in intervertebral discs, and delay the degeneration of intervertebral discs.
Randomized Controlled Clinical Study of Hand-Foot Luan Three-Needle Therapy in Treatment of Spastic Paralysis after Stroke
Vol 45,No. 07
Objective: A multi-centered, large sample, prospective randomized controlled clinical trial was designed to observe the clinical curative effect of spastic paralysis after stroke by Jin’s 3-needle therapy. Methods: We collected 166 cases of spastic paralysis in acute stage of stroke and randomly divided them into treatment group (Nie 3-needle therapy + hand-foot Luan 3-needle therapy, 82 cases), and control group (Nie 3-needle therapy + hand-foot 3-needle therapy, 84 cases). We observed the modified Ashworth spasticity scale (MAS), clinical spasticity index (CSI) scale, clinical neurological impairment score (NDS), limb motor function score, simplified Fugl-Meyer and ADL index (Barthel) before and after treatment. After evaluating and statistically analyzing the results, we observed the best acupoints combination of Jin’s 3-needle therapy in the treatment of spastic paralysis after stroke. Results: The total effective rate of the treatment group was 94.9%, while that of the control group was 90.2%, and the difference was statistically significant ( P < 0.05). The difference of the score of functional evaluation of two groups before and after treatment was statistically significant ( P < 0.01). Conclusion: The Jin’s 3-needle therapy, especially Nie 3-needle therapy + hand-foot Luan 3-needle therapy, has significant effect in treatment of spastic paralysis in acute stage of stroke. The therapy is worthy of popularization and application.