Sponsor(s): Second Military Medical University
12 issues per year
Current Issue: Issue 05, 2020
Scope of Contributions. AJSMMU welcomes manuscripts in Chinese and English on all aspects of biology and medicine from any part of the world. Original research articles (both basic science studies and clinical trials) are especially welcome. Short communications, review papers and case reports are also acceptable.
Editor-in-Chief: Wu Mengchao
Study on Traditional Chinese Medicine Syndrome Differentiation of Patients with Coronavirus Disease 2019
Academic Journal of Second Military Medical University,2020,Vol 41,No. 05
Objective To explore the pattern of traditional Chinese medicine (TCM) syndrome differentiation of patients with COVID-19. Methods The symptoms of 756 cases with COVID-19 in Guanggu District, Maternal and Child Health Care Hospital of Hubei Province were collected with cross-sectional survey. Frequency method was adopted for statistical analysis on the incidence rate of clinical symptoms. The common symptoms (incidence rate > 5.0%) were analyzed by cluster analysis according to different stages of the disease: prodromal stage (onset), middle stage (7–30 days), and later stage (> 30 days). Then the pattern of TCM syndrome differentiation of COVID-19 patients was explored in combination with the advice of experts. Results Fever (52.25%, 395/756), cough (43.25%, 327/756), fatigue (27.25%, 206/756), stuffiness in the chest (26.72%, 202/756), panting (17.59%, 133/756) and expectoration (5.03%, 38/756) were the most common symptoms in the prodromal stage, which were clustered into one category except expectoration, indicating the pathogenesis of dampness obstructing lung defense. In the middle stage of COVID-19 patients (383 cases), the 19 common symptoms of greasy fur (64.49%, 247 cases), yellow fur (43.86%, 168 cases), thick fur (40.21%, 154 cases), cough (34.73%, 133 cases), red tongue (32.38%, 124 cases), and hesitant bowel movement (25.85%, 99 cases), panting (25.33%, 97 cases), fatigue (25.07%, 96 cases), poor appetite (23.76%, 91 cases), bitter taste in mouth (14.36%, 55 cases), dry fur (12.01%, 46 cases), purplish tongue (12.01%, 46 cases), sweating in a deficient condition (11.49%, 44 cases), constipation (10.18%, 39 cases), whitish phlegm (8.62%, 33 cases), insomnia (7.31%, 28 cases), nausea (7.05%, 27 cases), diarrhea (6.79%, 26 cases) and yellow phlegm (6.27%, 24 cases) were clustered into three categories, indicating dampness obstructing the lungs and spleen, internal retention of dampness-heat and dampness-heat transforming into dryness. In the later stage of COVID-19 patients (373 cases), the 13 common symptoms of greasy fur (50.94%, 190 cases), fatigue (39.41%, 147 cases), cough (37.80%, 141 cases), red tongue (33.78%, 126 cases), panting (32.17%, 120 cases), sweating in a deficient condition (23.86%, 89 cases), dry mouth (22.79%, 85 cases), poor appetite (20.11%, 75 cases), hesitant bowel movement (19.30%, 72 cases), bitter taste in mouth (15.01%, 56 cases), whitish phlegm (10.72%, 40 cases), palpitation (8.31%, 31 cases) and scanty fur (8.04%, 30 cases) were clustered into two categories, suggesting a deficiency of both qi and yin with residual dampness, and lung-spleen qi deficiency with residual dampness. Conclusion the syndromes of COVID-19 patients have regular changes from exterior to interior, of dampness transforming into heat and excess developing to deficiency, with their own typical characteristics as the disease progresses.